Formulation and Evaluation of Gastroretentive Floating Microballoons of Anti diabetic drug
نویسندگان
چکیده
The objective of present investigation is to design a sustained release floating microballoons of Metformin HCl using two polymers of different permeability characteristics Cellulose Acetate Butyrate (MW of 16,000) and Eudragit RS 100 (MW of 150,000) using the oil-in-oil emulsion solvent evaporation method. The prepared microballoons were studied for drug release behavior in simulated gastric fluid at pH 1.2 and phosphate buffer at pH 6.8 respectively. Polymers were used separately and in combination (1:1) to prepare different microballoons using acetone as organic phase. In all batches of microballoons, the total polymer concentration was kept constant (10%w/w). No significant differences in drug loading for microballoons made of different polymer to polymer ratios were noted. Drug loaded microballoons were found to float on 0.1M HCl for more than 8 hour. FT-IR study showed no drug polymer interaction as evident from the FT-IR spectra. SEM study clearly reveals the smoothness of the spherically shaped particles. All the prepared microballoons showed higher amount of drug release in phosphate buffer (pH 6.8) as compared to the release in 0.1M HCl (pH 1.2). Evaluation of the release data reveals that microballoons prepared from RS 100, CAB and combination of both the polymers exhibit Higuchi spherical matrix release, followed by first order and zero-order release kinetics.
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